Scientific publications related to human milk analysis and fortification written by Preemie’s advisors

The below list comprehends publications and research related to human milk analysis and fortification carried out by Preemie’s advisors. They cover key topics such as analysis and fortification of human milk, oligosaccharides, breastfeeding and the use of donor milk, pathologies such as Necrotizing Enterocolitis (NEC), the processing of human milk to ensure quality and safety.

Fortification of Human Milk for Preterm Infants: Update and Recommendations of the European Milk Bank Association (EMBA) Working Group on Human Milk Fortification

[1] Arslanoglu, S., Boquien, C. Y., King, C., Lamireau, D., Tonetto, P., Barnett, D., Bertino, E., Gaya, A., Gebauer, C., Grovslien, A., Moro, G. E., Weaver, G., Wesolowska, A. M., and Picaud, J. C. (2019) Fortification of Human Milk for Preterm Infants: Update and Recommendations of the European Milk Bank Association (EMBA) Working Group on Human Milk Fortification, Frontiers in Pediatrics 7.

Donor Human Milk for Preterm Infants: Current Evidence and Research Directions

[2] Arslanoglu, S., Corpeleijn, W., Moro, G., Braegger, C., Campoy, C., Colomb, V., Decsi, T., Domellof, M., Fewtrell, M., Hojsak, I., Mihatsch, W., Molgaard, C., Shamir, R., Turck, D., van Goudoever, J., and Nutr, E. C. (2013), Journal of Pediatric Gastroenterology and Nutrition 57, 535-542.

Presence of human milk bank is associated with elevated rate of exclusive breastfeeding in VLBW infants

[3] Arslanoglu, S., Moro, G. E., Bellu, R., Turoli, D., De Nisi, G., Tonetto, P., and Bertino, E. (2013), Journal of Perinatal Medicine 41, 129-131.

Early supplementation of prebiotic oligosaccharides protects formula-fed infants against infections during the first 6 months of life

[4] Arslanoglu, S., Moro, G. E., and Boehm, G. (2007), Journal of Nutrition 137, 2420-2424.

Adjustable fortification of human milk fed to preterm infants: does it make a difference?

[5] Arslanoglu, S., Moro, G. E., and Ziegler, E. E. (2006), Journal of Perinatology 26, 614-621.

Preterm infants fed fortified human milk receive less protein than they need

[6] Arslanoglu, S., Moro, G. E., and Ziegler, E. E. (2009), Journal of Perinatology 29, 489-492.

Optimization of human milk fortification for preterm infants: new concepts and recommendations

[7] Arslanoglu, S., Moro, G. E., Ziegler, E. E., and Nutr, W. W. G. (2010), Journal of Perinatal Medicine 38, 233-238.

Donor human milk in preterm infant feeding: evidence and recommendations

[8] Arslanoglu, S., Ziegler, E. E., Moro, G. E., and Nutr, W. W. G. (2010), Journal of Perinatal Medicine 38, 347-351.

The influence of dietary nucleotides on erythrocyte membrane fatty acids and plasma lipids in preterm infants

[9] Axelsson, I., Flodmark, C. E., Raiha, N., Tacconi, M., Visentin, M., Minoli, I., Moro, G., and Warm, A. (1997), Acta Paediatrica 86, 539-544.

Effects of Holder pasteurization on human milk oligosaccharides

[10] Bertino, E., Coppa, G. V., Giuliani, F., Coscia, A., Gabrielli, O., Sabatino, G., Sgarrella, M., Testa, T., Zampini, L., and Fabris, C. (2008), International Journal of Immunopathology and Pharmacology 21, 381-385.

Effect of Prolonged Refrigeration on the Lipid Profile, Lipase Activity, and Oxidative Status of Human Milk

[11] Bertino, E., Giribaldi, M., Baro, C., Giancotti, V., Pazzi, M., Peila, C., Tonetto, P., Arslanoglu, S., Moro, G. E., Cavallarin, L., and Gastaldi, D. (2013), Journal of Pediatric Gastroenterology and Nutrition 56, 390-396.

New human milk fortifiers for the preterm infant

[12] Bertino, E., Giribaldi, M., Cester, E. A., Coscia, A., Trapani, B. M., Peila, C., Arslanoglu, S., Moro, G. E., and Cavallarin, L. (2017), Journal of Pediatric and Neonatal Individualized Medicine 6.

Benefits of donor milk in the feeding of preterm infants

[13] Bertino, E., Giuliani, F., Baricco, M., Di Nicola, P., Peila, C., Vassia, C., Chiale, F., Pirra, A., Cresi, F., Martano, C., and Coscia, A. (2013), Early Human Development 89, S3-S6.

Benefits of donor human milk for preterm infants: Current evidence

[14] Bertino, E., Giuliani, F., Occhi, L., Coscia, A., Tonetto, P., Marchino, F., and Fabris, C. (2009), Early Human Development 85, S9-S10.

Necrotizing Enterocolitis: Risk Factor Analysis and Role of Gastric Residuals in Very Low Birth Weight Infants

[15] Bertino, E., Giuliani, F., Prandi, G., Coscia, A., Martano, C., and Fabris, C. (2009), Journal of Pediatric Gastroenterology and Nutrition 48, 437-442.

Randomized, controlled trial of breastfeeding versus formula feeding in extremely low birth weight infants

[16] Bertino, E., Giuliani, F., Tonetto, P., Fabris, C., Profeti, C., Magnani, C., Moro, G. E., and Arslanoglu, S. (2006), Pediatrics 117, 985-986.

Donor Human Milk: Effects of Storage and Heat Treatment on Oxidative Stress Markers

[17] Bertino, E., Peila, C., Cresi, F., Maggiora, E., Sottemano, S., Gazzolo, D., Arslanoglu, S., and Coscia, A. (2018), Frontiers in Pediatrics 6.

Drugs and breastfeeding: instructions for use

[18] Bertino, E., Varalda, A., Di Nicola, P., Coscia, A., Occhi, L., Vagliano, L., Soldi, A., and Perathoner, C. (2012), Journal of Maternal-Fetal & Neonatal Medicine 25, 78-80.

Microbiota at Multiple Body Sites during Pregnancy in a Rural Tanzanian Population and Effects of Moringa-Supplemented Probiotic Yogurt

[19] Bisanz, J. E., Enos, M. K., PrayGod, G., Seney, S., Macklaim, J. M., Chilton, S., Willner, D., Knight, R., Fusch, C., Fusch, G., Gloor, G. B., Burton, J. P., and Reid, G. (2015), Applied and Environmental Microbiology 81, 4965-4975.

PROTEIN-QUALITY OF HUMAN-MILK FORTIFIER IN LOW-BIRTH-WEIGHT INFANTS - EFFECTS ON GROWTH AND PLASMA AMINO-ACID PROFILES

[20] Boehm, G., Borte, M., Bellstedt, K., Moro, G., and Minoli, I. (1993), European Journal of Pediatrics 152, 1036-1039.

Docosahexaenoic and arachidonic acid content of serum and red blood cell membrane phospholipids of preterm infants fed breast milk, standard formula or formula supplemented with n-3 and n-6 long-chain polyunsaturated fatty acids

[21] Boehm, G., Borte, M., Bohles, H. J., Muller, H., Kohn, G., and Moro, G. (1996), European Journal of Pediatrics 155, 410-416.

Prebiotics in infant formulas

[22] Boehm, G., Jelinek, J., Stahl, B., van Laere, K., Knol, J., Fanaro, S., Moro, G., and Vigi, V. (2004), Journal of Clinical Gastroenterology 38, S76-S79.

Structural and functional aspects of prebiotics used in infant nutrition

[23] Boehm, G., and Moro, G. (2008), Journal of Nutrition 138, 1818S-1828S.

NITROGEN AND FAT BALANCES IN VERY-LOW-BIRTH-WEIGHT INFANTS FED HUMAN-MILK FORTIFIED WITH HUMAN-MILK OR BOVINE-MILK PROTEIN

[24] Boehm, G., Muller, D. M., Senger, H., Borte, M., and Moro, G. (1993), European Journal of Pediatrics 152, 236-239.

Docosahexaenoic and arachidonic acid absorption in preterm infants fed LCP-free or LCP-supplemented formula in comparison to infants fed fortified breast milk

[25] Boehm, G., Muller, H., Kohn, G., Moro, G., Minoli, I., and Bohles, H. J. (1997), Annals of Nutrition and Metabolism 41, 235-241.

Prebiotic carbohydrates in human milk and formulas

[26] Boehm, G., Stahl, B., Jelinek, J., Knol, J., Miniello, V., and Moro, G. E. (2005), Acta Paediatrica 94, 18-21.

Target Fortification of Breast Milk: Predicting the Final Osmolality of the Feeds

[27] Choi, A., Fusch, G., Rochow, N., and Fusch, C. (2016), Plos One 11.

Establishment of micromethods for macronutrient contents analysis in breast milk

[28] Choi, A., Fusch, G., Rochow, N., Sheikh, N., and Fusch, C. (2015), Maternal and Child Nutrition 11, 761-772.

Antiviral oxysterols are present in human milk at diverse stages of lactation

[29] Civra, A., Leoni, V., Caccia, C., Sottemano, S., Tonetto, P., Coscia, A., Peila, C., Moro, G. E., Gaglioti, P., Bertino, E., Poli, G., and Lembo, D. (2019), Journal of Steroid Biochemistry and Molecular Biology 193.

Human milk glycosaminoglycans: the state of the art and future perspectives

[30] Coppa, G. V., Gabrielli, O., Bertino, E., Zampini, L., Galeazzi, T., Padella, L., Santoro, L., Marchesiello, R. L., Galeotti, F., Maccari, F., and Volpi, N. (2013), Italian Journal of Pediatrics 39.

Composition and structure elucidation of human milk glycosaminoglycans

[31] Coppa, G. V., Gabrielli, O., Buzzega, D., Zampini, L., Galeazzi, T., Maccari, F., Bertino, E., and Volpi, N. (2011), Glycobiology 21, 295-303.

Oligosaccharides in 4 Different Milk Groups, Bifidobacteria, and Ruminococcus obeum

[32] Coppa, G. V., Gabrielli, O., Zampini, L., Galeazzi, T., Ficcadenti, A., Padella, L., Santoro, L., Soldi, S., Carlucci, A., Bertino, E., and Morelli, L. (2011), Journal of Pediatric Gastroenterology and Nutrition 53, 80-87.

Glycosaminoglycan Content in Term and Preterm Milk during the First Month of Lactation

[33] Coppa, G. V., Gabrielli, O., Zampini, L., Galeazzi, T., Maccari, F., Buzzega, D., Galeotti, F., Bertino, E., and Volpi, N. (2012), Neonatology 101, 74-76.

Detection of cow’s milk proteins and minor components in human milk using proteomics techniques

[34] Coscia, A., Orru, S., Di Nicola, P., Giuliani, F., Varalda, A., Peila, C., Fabris, C., Conti, A., and Bertino, E. (2012), Journal of Maternal-Fetal & Neonatal Medicine 25, 57-59.

Effect of Holder Pasteurisation on Human Milk Glycosaminoglycans

[35] Coscia, A., Peila, C., Bertino, E., Coppa, G. V., Moro, G. E., Gabrielli, O., Zampini, L., Galeazzi, T., Maccari, F., and Volpi, N. (2015), Journal of Pediatric Gastroenterology and Nutrition 60, 127-130.

Inactivation of high-risk human papillomaviruses by Holder pasteurization: implications for donor human milk banking

[36] Donalisio, M., Cagno, V., Vallino, M., Moro, G. E., Arslanoglu, S., Tonetto, P., Bertino, E., and Lembo, D. (2014), Journal of Perinatal Medicine 42, 1-8.

High Temperature-Short Time Pasteurization Has a Lower Impact on the Antiviral Properties of Human Milk Than Holder Pasteurization

[37] Donalisio, M., Ritta, M., Francese, R., Civra, A., Tonetto, P., Coscia, A., Giribaldi, M., Cavallarin, L., Moro, G. E., Bertino, E., and Lembo, D. (2018), Frontiers in Pediatrics 6.

Galacto-oligosaccharides Are Bifidogenic and Safe at Weaning: A Double-blind Randomized Multicenter Study

[38] Fanaro, S., Marten, B., Bagna, R., Vigi, V., Fabris, C., Pena-Quintana, L., Arguelles, F., Scholz-Ahrens, K. E., Sawatzki, G., Zelenka, R., Schrezenmeir, J., de Vrese, M., and Bertino, E. (2009), Journal of Pediatric Gastroenterology and Nutrition 48, 82-88.

Quantification of lactose content in human and cow’s milk using UPLC-tandem mass spectrometry

[39] Fusch, G., Choi, A., Rochow, N., and Fusch, C. (2011), Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 879, 3759-3762.

Need of quality control programme when using near-infrared human milk analyzers

[40] Fusch, G., Kwan, C., Huang, R. C., Rochow, N., and Fusch, C. (2016), Acta Paediatrica 105, 324-325.

"Bed Side" Human Milk Analysis in the Neonatal Intensive Care Unit A Systematic Review

[41] Fusch, G., Kwan, C., Kotrri, G., and Fusch, C. (2017), Clinics in Perinatology 44, 209-+.

Target fortification of breast milk: levels of fat, protein or lactose are not related

[42] Fusch, G., Mitra, S., Rochow, N., and Fusch, C. (2015), Acta Paediatrica 104, 38-42.

Source and Quality of Enteral Nutrition Influences Oxidative Stress in Preterm Infants: A Prospective Cohort Study

[43] Fusch, G., Mitra, S., Topp, H., Agarwal, A., Yiu, S. H., Bruhs, J., Rochow, N., Lange, A., Heckmann, M., and Fusch, C. (2018), Journal of Parenteral and Enteral Nutrition 42, 1288-1294.

Rapid measurement of macronutrients in breast milk: How reliable are infrared milk analyzers?

[44] Fusch, G., Rochow, N., Choi, A., Fusch, S., Poeschl, S., Ubah, A. O., Lee, S. Y., Raja, P., and Fusch, C. (2015), Clinical Nutrition 34, 465-476.

Preterm Milk Oligosaccharides During the First Month of Lactation

[45] Gabrielli, O., Zampini, L., Galeazzi, T., Padella, L., Santoro, L., Peila, C., Giuliani, F., Bertino, E., Fabris, C., and Coppa, G. V. (2011), Pediatrics 128, E1520-E1531.

Effect of prolonged refrigeration on the protein and microbial profile of human milk

[46] Giribaldi, M., Ortoffi, M. F., Giuffrida, M. G., Gastaldi, D., Peila, C., Coscia, A., Raia, M., Arslanoglu, S., Moro, G. E., Cavallarin, L., and Bertino, E. (2013), International Dairy Journal 31, 121-126.

Validation of Correction Algorithms for Near-IR Analysis of Human Milk in an Independent Sample Set-Effect of Pasteurization

[47] Kotrri, G., Fusch, G., Kwan, C., Choi, D., Choi, A., Al Kafi, N., Rochow, N., and Fusch, C. (2016), Nutrients 8.

Infrared analyzers for breast milk analysis: fat levels can influence the accuracy of protein measurements

[48] Kwan, C., Fusch, G., Bahonjic, A., Rochow, N., and Fusch, C. (2017), Clinical Chemistry and Laboratory Medicine 55, 1931-1935.

A new formula for premature infants: effects on growth and nutritional status

[49] Marseglia, L., Pagano, G., Arco, A., Barberi, I., Biasucci, G., Riboni, S., Mondello, I., Fiamingo, C., and Moro, G. (2015), Journal of Maternal-Fetal & Neonatal Medicine 28, 1482-1485.

Prebiotics in infant milk formulas: new perspectives

[50] Miniello, V. L., Moro, G. E., and Armenio, L. (2003), Acta Paediatrica 92, 68-76.

Reproducing the bifidogenic effect of human milk in formula-fed infants: Why and how?

[51] Moro, G. E., and Arslanoglu, S. (2005), Acta Paediatrica 94, 14-17.

Adherence to the Traditional Mediterranean Diet and Human Milk Composition: Rationale, Design, and Subject Characteristics of the MEDIDIET Study

[52] Moro, G. E., Bertino, E., Bravi, F., Tonetto, P., Gatta, A., Quitadamo, P. A., Salvatori, G., Profeti, C., Di Nicola, P., Decarli, A., Ferraroni, M., Tavani, A., Stahl, B., and Wiens, F. (2019), Frontiers in Pediatrics 7.

Processing of Donor Human Milk: Update and Recommendations From the European Milk Bank Association (EMBA)

[53] Moro, G. E., Billeaud, C., Rachel, N., Calvo, J., Cavallarin, L., Christen, L., Escuder-Vieco, D., Gaya, A., Lembo, D., Wesolowska, A., Arslanoglu, S., Barnett, D., Bertino, E., Boquien, C. Y., Gebauer, C., Grovslien, A., Weaver, G. A., and Picaud, J. C. (2019), Frontiers in Pediatrics 7.

GROWTH AND METABOLIC RESPONSES IN LOW-BIRTH-WEIGHT INFANTS FED HUMAN-MILK FORTIFIED WITH HUMAN-MILK PROTEIN OR WITH A BOVINE-MILK PROTEIN PREPARATION

[54] Moro, G. E., Minoli, I., Fulconis, F., Clementi, M., and Raiha, N. C. R. (1991), Journal of Pediatric Gastroenterology and Nutrition 13, 150-154.

FORTIFICATION OF HUMAN-MILK - EVALUATION OF A NOVEL FORTIFICATION SCHEME AND OF A NEW FORTIFIER

[55] Moro, G. E., Minoli, I., Ostrom, M., Jacobs, J. R., Picone, T. A., Raiha, N. C. R., and Ziegler, E. E. (1995), Journal of Pediatric Gastroenterology and Nutrition 20, 162-172.

Dietary prebiotic oligosaccharides are detectable in the faeces of formula-fed infants

[56] Moro, G. E., Stahl, B., Fanaro, S., Jelinek, J., Boehm, G., and Coppa, G. V. (2005), Acta Paediatrica 94, 27-30.

A mixture of prebiotic oligosaccharides reduces the incidence of atopic dermatitis during the first six months of age, Archives of Disease in Childhood 91

[57] Moro, G., Arslanoglu, S., Stahl, B., Jelinek, J., Wahn, U., and Boehm, G. (2006), 814-819.

Dosage-related bifidogenic effects of galacto- and fructooligosaccharides in formula-fed term infants

[58] Moro, G., Minoli, I., Mosca, M., Fanaro, S., Jelinek, J., Stahl, B., and Boehm, G. (2002), Journal of Pediatric Gastroenterology and Nutrition 34, 291-295.

Cow’s milk allergens identification by two-dimensional immunoblotting and mass spectrometry

[59] Natale, M., Bisson, C., Monti, G., Peltran, A., Garoffo, L. P., Valentini, S., Fabris, C., Bertino, E., Coscia, A., and Conti, A. (2004), Molecular Nutrition & Food Research 48, 363-369.

Effects of Holder pasteurization on the protein profile of human milk

[60] Peila, C., Coscia, A., Bertino, E., Cavaletto, M., Spertino, S., Icardi, S., Tortone, C., Visser, G. H. A., and Gazzolo, D. (2016), Italian Journal of Pediatrics 42.

Donor Human Milk and Its Nutritional Properties: What Should We Believe?

[61] Peila, C., Coscia, A., Bertino, E., Cavallarin, L., Giribaldi, M., and Moro, G. E. (2016), Journal of Human Lactation 32, 390-391.

Human Milk Adrenomedullin Is Unstable During Cold Storage at 4 degrees C

[62] Peila, C., Coscia, A., Bertino, E., Li Volti, G., Galvano, F., Barbagallo, I., and Gazzolo, D. (2017), Breastfeeding Medicine 12, 561-565.

The Effect of Holder Pasteurization on Activin A Levels in Human Milk

[63] Peila, C., Coscia, A., Bertino, E., Volti, G. L., Galvano, F., Barbagallo, I., Visser, G. H. A., and Gazzolo, D. (2016), Breastfeeding Medicine 11, 469-473.

Human Milk Processing: A Systematic Review of Innovative Techniques to Ensure the Safety and Quality of Donor Milk

[64] Peila, C., Emmerik, N. E., Giribaldi, M., Stahl, B., Ruitenberg, J. E., van Elburg, R. M., Moro, G. E., Bertino, E., Coscia, A., and Cavallarin, L. (2017), Journal of Pediatric Gastroenterology and Nutrition 64, 353-361.

The Effect of Holder Pasteurization on Nutrients and Biologically-Active Components in Donor Human Milk: A Review

[65] Peila, C., Moro, G. E., Bertino, E., Cavallarin, L., Giribaldi, M., Giuliani, F., Cresi, F., and Coscia, A. (2016), Nutrients 8.

GROWTH, SERUM BIOCHEMISTRIES, AND AMINO-ACIDS OF TERM INFANTS FED FORMULAS WITH AMINO-ACID AND PROTEIN CONCENTRATIONS SIMILAR TO HUMAN-MILK

[66] Picone, T. A., Benson, J. D., Moro, G., Minoli, I., Fulconis, F., Rassin, D. K., and Raiha, N. C. R. (1989), Journal of Pediatric Gastroenterology and Nutrition 9, 351-360.

Individualized protein fortification of human milk for preterm infants: Comparison of ultrafiltrated human milk protein and a bovine whey fortifier

[67] Polberger, S., Raiha, N. C. R., Juvonen, P., Moro, G. E., Minoli, I., and Warm, A. (1999), Journal of Pediatric Gastroenterology and Nutrition 29, 332-338.

MILK PROTEIN-INTAKE IN THE TERM INFANT .1. METABOLIC RESPONSES AND EFFECTS ON GROWTH

[68] Raiha, N., Minoli, I., and Moro, G. (1986), Acta Paediatrica Scandinavica 75, 881-886.

MILK PROTEIN-INTAKE IN THE TERM INFANT .2. EFFECTS ON PLASMA AMINO-ACID-CONCENTRATIONS

[69] Raiha, N., Minoli, I., Moro, G., and Bremer, H. J. (1986), Acta Paediatrica Scandinavica 75, 887-892.

Target Fortification of Breast Milk with Fat, Protein, and Carbohydrates for Preterm Infants

[70] Rochow, N., Fusch, G., Choi, A., Chessell, L., Elliott, L., McDonald, K., Kuiper, E., Purcha, M., Turner, S., Chan, E., Xia, M. Y., and Fusch, C. (2013), Journal of Pediatrics 163, 1001-1007.

A nutritional program to improve outcome of very low birth weight infants

[71] Rochow, N., Fusch, G., Muhlinghaus, A., Niesytto, C., Straube, S., Utzig, N., and Fusch, C. (2012), Clinical Nutrition 31, 124-131.

Target Fortification of Breast Milk: How Often Should Milk Analysis Be Done?

[72] Rochow, N., Fusch, G., Zapanta, B., Ali, A., Barui, S., and Fusch, C. (2015), Nutrients 7, 2297-2310.

Levels of lipids in preterm infants fed breast milk

[73] Rochow, N., Moller, S., Fusch, G., Drogies, T., and Fusch, C. (2010), Clinical Nutrition 29, 94-99.

Non-digestible oligosaccharides reduce immunoglobulin free light-chain concentrations in infants at risk for allergy

[74] Schouten, B., Van Esch, B., Kormelink, T. G., Moro, G. E., Arslanoglu, S., Boehm, G., Knippels, L. M. J., Redegeld, F. A., Willemsen, L. E. M., and Garssen, J. (2011), Pediatric Allergy and Immunology 22, 537-542.

Neonatal jaundice and human milk

[75] Soldi, A., Tonetto, P., Varalda, A., and Bertino, E. (2011), Journal of Maternal-Fetal & Neonatal Medicine 24, 85-87.

Zinc supplementation reduces morbidity and mortality in very-low-birth-weight preterm neonates: a hospital-based randomized, placebo-controlled trial in an industrialized country

[76] Terrin, G., Canani, R. B., Passariello, A., Messina, F., Conti, M. G., Caoci, S., Smaldore, A., Bertino, E., and De Curtis, M. (2013), American Journal of Clinical Nutrition 98, 1468-1474.

Human milk analyser underestimated protein content of unfortified and fortified samples compared to elemental analysis

[77] Thajer, A., Fusch, G., Binder, C., Berger, A., and Fusch, C. (2019), Acta Paediatrica 108, 2298-2300.

A specific mixture of short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides induces a beneficial immunoglobulin profile in infants at high risk for allergy

[78] van Hoffen, E., Ruiter, B., Faber, J., M’Rabet, L., Knol, E. F., Stahl, B., Arslanoglu, S., Moro, G., Boehm, G., and Garssen, J. (2009), Allergy 64, 484-487.

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No.879228.

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