Unleashing the clinical adoption of
targeted fortification of the nutrient
content of human milk

Doctor assisting a preterm infant in the Neonatal Intensive Therapy Unit

Personalise and track the nutritional
intake and growth of preterm infants

Helping accelerate progress towards
the goal of decreasing deaths and life-longing
disabilities due to preterm birth

PREEMIE NEWS - EU HORIZON MAGAZINE

Universal health equity
for every preemie

Preemie is the first clinical neonatal system that provides data-driven decision support for optimal and personalised feeding and care of preterm infants

Prematurity is not only the leading cause of mortality in children but can also result in devastating diseases such as necrotising enterocolitis (NEC), as well as in long-term disorders and sequelae such as vision and hearing problems. Besides the tremendous impact on the quality of life of preterm infants and their families, the economic burden for the whole society is huge.

The Preemie ecosystem helps reduce the risks associated with premature birth by enabling a rapid and affordable analysis of human milk composition, and delivering data-driven calculations for the targeted fortification needed to meet the unique nutritional needs of each preterm infant. The system also provides in real-time a time-stamped visualisation and analysis of the infant’s growth-related data and the corresponding nutrition given, thus supporting a retrospective understanding of fortification metrics and growth outcomes.

Enables human milk rapid and affordable analysis in their current clinical workflow, thus allowing individualized targeted fortification

Delivers data-driven calculations of the milk fortification needed, thus speeding up feeding operations and making it less error-prone

Provides a data-driven decision support system to enable clinicians optimize preterm feeding

Reduces hospital length of stay for preterm infants based on the benefits of targeted fortification

Provides in real-time a time-stamped visualisation and analysis of the infant growth-related data and the corresponding nutrition given

Provides a reduction of 4% in the occurrence of NEC, 4% for BPD, and 10% for sepsis based the benefits of targeted fortification

The Preemie ecosystem

Preemie ecosystem is composed of:

1. Preemie Sensor

a portable NIR spectrometer that scans the human milk to be analysed, generates a spectrum;

2. The Milk Analysis software

which runs on an Android tablet, receives the milk spectrum and sends it to the AI engine for analysis, and then displays and prints the milk analysis results;

3. The milk analysis engine

in the cloud, that uses deep learning models to provide the concentrations of nutrients in the milk, based on the spectrum received;

4. The NutriNTrack software

suggests the personalised milk fortification needed for each preterm, based on milk analysis, the infant’s clinical data, historical feeding protocols, the infant’s risk scores for certain conditions, nutritional guidelines, and the fortifiers available. This software also provides real-time visualisation and analysis of the infant’s growth-related data and the corresponding nutrition given over a chosen time period, thus supporting data-driven decisions on the feeding strategy.

5. The risk scores engine

in the cloud, that uses deep learning models to generate predictive risk scores for a preterm infant to develop conditions that are affected by nutrition, calculates the nutrient and its respective concentrations to be added to the human milk in order to counteract the high risks found, and feeds this information to the NutriNTrack software.

The Preemie ecosystem has obtained the CE Marking and is currently being certified as an In Vitro Diagnostic (IVD) device.

Preemie system
For Neonatal Units

1. Preemie Sensor and Milk Analysis software
Preemie Sensor is a portable NIR spectrometer supported by our AI engine to analyse the composition of human milk. The Milk Analysis software runs on an Android tablet and operates Preemie Sensor. The user can identify the milk to be analysed through a specific code, or just by scanning a barcode. To analyse the milk, the user places a couple of drops of homogenised breast milk into our patented cuvette, inserts it into the sensor, and presses the scan button. The tablet receives the spectrum from the sensor and sends it to the cloud. After the spectrum has been processed by the AI engine in the cloud, the results of the analysis are displayed on the tablet. This entire process takes 20 seconds. The user can also export or print a report on the results obtained.

The sensor is portable.
Sample preparation is fast and easy
Results are displayed and saved quickly
There are no consumables
Calibration is quick and is needed only daily
Just two drops of milk are needed (0.35 ml)
Cuvette cleaning is easy
Compliant with GDPR and HIPAA

2. Preemie Tracker software for Neonatal Intensive Care Units
This software works with or without Preemie Sensor. It uses an AI data-driven approach to calculate the recommended personalised fortification of the human milk being used for feeding a specific preterm infant. The process is completely automated, and clinicians have a simple interface to accept or modify this fortification. The software takes in consideration the fortifiers available, the volume of the milk to be administered, and the number of feedings, and suggests the exact fortifiers to be used as well as their respective volumes in order to achieve the fortification required. Once the feeding is administered, the user can enter the exact volume of milk the infant actually ingested. This software also displays growth-restriction risk scores so as to support data-driven decisions on the best feeding strategy. It helps to correlate actual nutritional intake, including the fortification done, to growth indicators, and to get insights into the evolution of the infant’s health metrics. It also enables a timestamped visualisation of the nutrition administered and the growth charts (Fenton or Olsen), including growth velocity. All the data can be saved in a report, exported, or printed.

Calculations of milk fortification based on a data-driven approach
Real-time clinical decision support tool for preterm feeding
Provides AI generated risk scores for conditions affected by nutrition
Tracks infant’s nutrition intake and growth over time
Enter, save, and print data about infant growth and nutrition
Compliant with GDPR and HIPAA

Preemie Sensor + Milk Analysis software + NutriNTrack software

How the Preemie system works at the NICU

Preemie system
For Human Milk Banks

1. Preemie Milk Quality software for Human Milk Banks
Preemie Sensor is a portable NIR spectrometer supported by our AI engine to analyse the composition of human milk. The Milk Analysis software runs on an Android tablet and operates Preemie Sensor. The user can identify the milk to be analysed through a specific code, or just by scanning a barcode. To scan the milk, the user places a couple of drops of homogenised breast milk into our patented cuvette, inserts it into the sensor, and presses the scan button. The tablet receives the spectrum from the sensor and sends it to the cloud. After the spectrum has been processed by the AI engine in the cloud, the results of the analysis are displayed on the tablet. This entire process takes 20 seconds. The user can also export or print a report on the results obtained.

Perform human milk composition analysis
Print labels with information, such as nutritional information, that can be placed on the milk bags
Sample preparation is fast and easy
Results are displayed and saved quickly
There are no consumables
Calibration is quick and is needed only daily
Just two drops of milk are needed (0.35 ml)
Cuvette cleaning is easy

2. NutriNTrack software: module for Human Milk Banks
The Preemie NutriNTrack software has a module that is specifically dedicated for human milk banks to manage the donor milk, encompassing all the key steps, from reception to storage, up to processing and delivery, as well as to optimise the milk pooling process for getting tailored pooled milk.

Management of the donor milk received
Automatic optimization of pooled milk in order to produce a tailored pool of milk with specific nutritional content
Print labels including history data and nutritional content for each donor and pooled milk bag
Store relevant data about donor milk in compliance with GDPR and HIPAA

Preemie Sensor + Milk Analysis software + NutriNTrack software: module for Human Milk Bank

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This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No.879228.

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Helping accelerate progress towards the goal of decreasing deaths and life-longingdisabilities due to preterm birth